AI-Driven Drug Discovery: Small Molecule NCT-503 Shows Promise in Treating Alzheimer's

Researchers at UC San Diego used AI to identify a small molecule, NCT-503, that targets the PHGDH enzyme and alleviates Alzheimer's disease progression in mouse models. NCT-503 effectively crosses the blood-brain barrier and significantly improved memory and anxiety symptoms in mice. While limitations exist, such as the lack of a perfect animal model for spontaneous Alzheimer's, the results show significant promise for NCT-503 as a potential therapeutic, paving the way for further development and clinical trials.