Unlocking Microbial Dark Matter: New Antibiotics Discovered in Soil

Researchers at Rockefeller University have developed a novel method to access the genetic potential of unculturable bacteria residing in soil. By extracting large DNA fragments directly from soil, they bypassed the need for lab cultivation and sequenced hundreds of previously unseen bacterial genomes. This yielded two promising new antibiotic leads, one of which, erutacidin, effectively targets drug-resistant bacteria. This scalable approach opens a new era of drug discovery and provides insights into the vast, unexplored microbial world shaping our environment.