Webtagr - Technology News Summarizer

Popular：

Virtualization DNS security formal verification reachability analysis compiler errors macro conflict web extension development framework Bitmap Graphics API inconsistencies All Tags

Unlocking Microbial Dark Matter: New Antibiotics Discovered in Soil

2025-09-25

Researchers at Rockefeller University have developed a novel method to access the genetic potential of unculturable bacteria residing in soil. By extracting large DNA fragments directly from soil, they bypassed the need for lab cultivation and sequenced hundreds of previously unseen bacterial genomes. This yielded two promising new antibiotic leads, one of which, erutacidin, effectively targets drug-resistant bacteria. This scalable approach opens a new era of drug discovery and provides insights into the vast, unexplored microbial world shaping our environment.

Local Injection of Novel Immunotherapy Triggers Systemic Tumor Regression

2025-09-10

Researchers at Rockefeller University have developed a novel CD40 agonist antibody, 2141-V11, which has yielded remarkable results in a Phase 1 clinical trial. Administered directly into tumors, rather than intravenously, the drug significantly reduced side effects. Of 12 patients with metastatic cancer, six saw tumor shrinkage, with two achieving complete remission – meaning their cancer disappeared entirely. Remarkably, this localized injection triggered a systemic immune response capable of eliminating tumors elsewhere in the body. This research offers new hope for cancer immunotherapy, and further studies will explore the mechanism of action and patient selection criteria to improve efficacy.