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Category: Tech

From Animal 'Factories' to Synthetic Biology: A Revolution in Biopharming

2024-12-15

Historically, many medicines and materials relied on animal extraction, such as antivenom from horse blood, endotoxin detection from horseshoe crab blood, and silk from silkworms. This article traces the journey from ancient Phoenicians using snails to extract Tyrian purple dye to the modern use of biotechnology to synthesize insulin, antibodies, and vaccines. While synthetic biology technologies can now replace many animal-derived products, some areas still rely on animals due to regulatory lag, molecular complexity, and challenges in scaling production, such as influenza vaccine production. The article highlights the enormous potential of synthetic biology to improve efficiency and reduce animal use, but also reminds us of the importance of protecting biodiversity, as the development of biotechnology also relies on exploration and utilization of the natural world.

(worksinprogress.co)
Tech animal welfare

BioNTech's Bispecific Antibody Shows Promise in Triple-Negative Breast Cancer

2024-12-15

BioNTech presented early clinical trial data for its novel bispecific antibody, BNT-327, at the San Antonio Breast Cancer Symposium. Targeting PD-1/PD-L1 and VEGF, the antibody showed positive results in patients with triple-negative breast cancer. Building on the discovery of checkpoint inhibitors, this research represents a potential breakthrough in next-generation immunotherapy, offering hope for new treatments in triple-negative breast cancer and potentially other cancers.

(www.statnews.com)
Tech bispecific antibody immunotherapy triple-negative breast cancer

Recursion Pharmaceuticals Ditches Cell Painting for Brightfield Imaging

2024-12-15

Recursion Pharmaceuticals, a biotech leveraging machine learning for drug discovery, recently announced a surprising shift: abandoning its signature cell painting technique in favor of traditional brightfield imaging. This article delves into the reasons behind this change. Advances in deep learning allow models to effectively process raw images, diminishing the value of cell painting's fluorescent dyes for contrast enhancement. Brightfield imaging offers advantages in cost, ease of implementation, and compatibility with live-cell time-lapse microscopy, opening up possibilities for studying cellular dynamics. Despite the seemingly risky move, internal testing at Recursion shows brightfield imaging yielding comparable or even superior results in predicting drug perturbations.

(www.owlposting.com)
Tech cell imaging drug development

Efficient Cloud-Native Raster Data Access: An Alternative to Rasterio/GDAL

2024-12-15

The exponential growth of Earth observation data in cloud storage necessitates efficient access and analysis of satellite imagery. This article introduces an alternative cloud-native raster data access approach to Rasterio/GDAL. Traditional GeoTIFFs are inefficient, while Cloud-Optimized GeoTIFFs (COGs) improve efficiency through tiling and multi-resolution access. However, even with COGs, tasks like time-series NDVI analysis suffer from latency. The authors leverage STAC GeoParquet, combined with pre-calculated byte ranges, to reduce HTTP requests, significantly speeding up data access. Initial tests show this approach drastically reduces time-to-first-tile for Sentinel-2 data and lowers costs. A future open-source library, "Rasteret," will implement these techniques.

(blog.terrafloww.com)
Tech Cloud-native Raster data

How Big Data Revolutionized the Modern Dairy Cow

2024-12-15

This article chronicles the US dairy industry's transformation into a global leader in cattle genetics, driven by big data and public-private partnerships. Starting with cow-testing cooperatives and the Babcock test, advancements like artificial insemination and cryogenic preservation, culminating in genomic sequencing, dramatically increased milk production. However, this success has led to inbreeding and climate change concerns. The future of dairy genetics requires balancing high yields with sustainability, necessitating industry collaboration and innovation.

(worksinprogress.co)
Tech Big Data Cattle Genetics Agricultural Technology

Exploring Climate Classification Systems: Beyond Köppen-Geiger

2024-12-14

This article delves into climate classification systems for Earth and beyond. It begins by introducing the widely used Köppen-Geiger system and its limitations. The author then analyzes various modifications and alternatives, including Trewartha, FAO, and Holdridge systems, comparing their differences in parameter selection, seasonality representation, and applicability. Ultimately, the author highlights the Prentice et al. BIOME1 model as a superior option due to its parameter choices and predictive accuracy, offering valuable insights for building more versatile climate classification systems.

(worldbuildingpasta.blogspot.com)
Tech climate classification Köppen-Geiger BIOME1 model

Century-Scale Digital Storage: A Race Against Time

2024-12-14

This article explores the challenge of storing digital data for 100 years. From the invention of IBM's first hard drive-equipped computer, RAMAC, to the prevalence of cloud storage today, the author analyzes the advantages and disadvantages of various storage methods, including hard drives, cloud storage, removable media, and physical imprinting or printing. The article highlights the threats to long-term data preservation, such as physical damage to hardware, software updates, institutional changes, and market fluctuations. Ultimately, the author argues that the key to century-scale digital storage lies in establishing a culture that values maintenance and preservation, requiring a collective effort from all sectors of society to combat the erosion of time and safeguard humanity's digital heritage.

(lil.law.harvard.edu)
Tech data storage digital archive long-term preservation

Scientists Discover Four New Species of Portuguese Man-of-War

2024-12-14

Recent research has uncovered four new species of the Portuguese man-of-war, challenging our understanding of this venomous creature. Far from being a single organism, the man-of-war is a colony of four or five distinct individuals, each responsible for functions like floating, stinging, digestion, and reproduction. This unique colonial structure is a marvel of natural engineering. Adding to its intrigue, the man-of-war inflates its float using carbon monoxide and reproduces via a mysterious process with poorly understood larval development. Furthermore, a parasitic fish, the bluebottle, feeds on the man-of-war's tentacles and gonads, further highlighting the species' complexity.

(crookedtimber.org)
Tech Portuguese man-of-war new species marine biology

Through-the-Earth Communication: Revolutionizing Underground Connectivity

2024-12-14

Traditional radio waves struggle to penetrate rock, making communication in mines and caves challenging. This article explores Through-the-Earth (TTE) communication, utilizing ultra-low frequency (300-3000 Hz) signals that propagate through rock strata. TTE systems, including portable magnetic-loop cave radios, Personal Emergency Devices (PEDs), and the innovative 'Miner Lifeline' technology, are highlighted for their crucial role in mine rescue operations and cave exploration, even after catastrophic events like fires or explosions.

(en.wikipedia.org)
Tech Through-the-Earth Communication Mine Communication Emergency Rescue

Antimatter Propulsion: The Future of Space Exploration?

2024-12-14

A groundbreaking technology, antimatter propulsion, holds the potential to revolutionize space exploration. Antimatter annihilation offers the highest known energy density, with 100% efficiency, theoretically enabling voyages across the solar system in mere weeks or even days. However, significant challenges remain in producing, storing, and controlling antimatter, keeping the technology firmly in the theoretical realm for now. Further research and development are crucial to unlock its immense potential.

(www.sciencedirect.com)
Tech antimatter space exploration propulsion technology

YouTube quietly downgraded its web embeds, impacting user experience

2024-12-14

YouTube recently altered its Publisher for Publishers (PfP) embedded player, removing the title link back to YouTube. This change, intended to protect advertisers since PfP allows publishers to sell their own ads, means many websites, including The Verge, now have YouTube embeds where clicking the title no longer opens the video on YouTube.com or the app. Despite efforts to communicate with YouTube, including reaching out to CEO Neal Mohan, the change remains. This highlights how large tech platforms can prioritize their own interests over user experience.

(www.theverge.com)
Tech embedded player

Agricultural Trade in Tropical Regions Causes Biodiversity Loss Three Times Higher Than Thought

2024-12-14

A study published in Nature Sustainability reveals that agricultural exports from tropical regions are three times more damaging to biodiversity than previously assumed. Researchers from the Technical University of Munich and ETH Zurich tracked how agricultural exports from 1995 to 2022 affected land-use changes in producing countries. International trade is responsible for over 90% of biodiversity loss during this period, impacting Brazil, Indonesia, Mexico, and Madagascar particularly severely. The team used satellite data to more accurately assess the long-term impacts of land-use change on biodiversity, highlighting the complex link between global trade and biodiversity loss. The study calls for global action to address this challenge.

(phys.org)
Tech biodiversity agricultural trade land use change land-use change biodiversity loss

Is Creating a Perfectly Spherical Prince Rupert's Drop Possible?

2024-12-14

An engineering question explores the possibility of creating a perfectly spherical Prince Rupert's drop. Prince Rupert's drops are glass objects formed by dripping molten glass into cold water, their unique internal stresses making them incredibly tough except at the tail. The article discusses how, theoretically, in a zero-gravity environment by controlling the cooling rate and removing the effects of gravity, a spherical Prince Rupert's drop could be made, but significant practical challenges remain.

(engineering.stackexchange.com)
Tech Prince Rupert's Drop Glass Material Science

Battery-Free Energy-Harvesting Holiday Card Unveiled

2024-12-14

In 2024, Jeff Keacher, Sean Beever, and Sophie created a battery-free electronic holiday card. This ingenious card cleverly harvests ambient radio waves and light energy (not from a traditional solar panel) to power its LEDs and is remotely controllable via a 2.4 GHz WiFi network. Designed for maximum power efficiency, it averages just 400 nanowatts of power consumption and can even be powered by the RF energy leaked from a microwave oven.

(www.keacher.com)
Tech energy-harvesting battery-free wireless control

IPv6: Schrödinger's Internet Protocol

2024-12-13

IPv6, designed to address the anticipated internet address exhaustion crisis, exists in a paradoxical state. Its deployment steadily expands, connecting more users and devices; yet it seems stalled, overshadowed by the enduring dominance of IPv4 solutions. This article explores the complexities of IPv6 adoption, including the role of NAT, IPv4 address transfers, and inconsistent vendor and application developer readiness. It analyzes different government strategies in promoting IPv6, and how incentives, vendor accountability, and capacity-building initiatives can foster adoption. Ultimately, it highlights IPv6's importance in preserving the internet as an open platform for innovation.

(labs.ripe.net)
Tech Internet Protocol Network Technology

NASA Solves Ingenuity Mars Helicopter Crash Mystery

2024-12-13

After nearly a year of investigation, NASA has finally solved the mystery behind the crash of Ingenuity, the Mars helicopter carried by the Perseverance rover. The helicopter's navigation system, unable to discern sufficient features on the relatively smooth Martian surface, resulted in a horizontal velocity upon landing. This caused Ingenuity to tumble, breaking its blades. Despite lacking a black box, investigators pieced together the cause from limited data and imagery. Remarkably, Ingenuity still communicates intermittently with Perseverance. The incident has prompted NASA to begin planning for follow-on missions, including a larger Mars helicopter capable of carrying scientific instruments.

(arstechnica.com)
Tech Mars exploration Ingenuity navigation system failure

HP 9845C: A Colorful Pioneer of 80s Computer Graphics

2024-12-13

In 1981, the HP 9845C, the top-of-the-line model in the 9845 series, emerged as the first HP computer to support color, stunning the world with its powerful graphics capabilities. Featuring hardware-accelerated vector drawing and polygon fill, and supporting fast matrix operations for 3D model rendering, this machine initially designed for scientific and engineering use quickly became a multipurpose system, even contributing to the graphic scenes in the 1983 film "WarGames." Its demo program was remarkable, boasting over 4000 lines of code and showcasing cutting-edge concepts like 3D shading, ordered dithering, wireframe rendering, interactive light pen control, and color infographics at a high resolution of up to 4913 colors.

(socks-studio.com)
Tech computer graphics vintage computer

Major Breakthrough in Nuclear Clock Technology Promises Ultraprecise Timekeeping

2024-12-13

An international research team led by scientists at JILA, a joint institute of the National Institute of Standards and Technology (NIST) and the University of Colorado Boulder, has made a significant advance in developing a novel nuclear clock. Nuclear clocks use energy transitions within an atom's nucleus to measure time, promising greater accuracy and resistance to external disturbances compared to atomic clocks. The team used a specially designed ultraviolet laser to precisely measure the frequency of an energy jump in thorium nuclei and an optical frequency comb to count the cycles. This breakthrough paves the way for more precise navigation, faster internet speeds, and advancements in fundamental physics research, potentially even aiding in the detection of dark matter or verifying the constancy of nature's constants.

(www.nist.gov)
Tech nuclear clock ultraprecise timekeeping physics

Italian Town Solves Winter Darkness with Giant Mirror

2024-12-13

Nestled in a valley between Italy and Switzerland, the town of Viganella suffers from three months of winter darkness each year. To combat this, in 2006, residents ingeniously installed a massive mirror on a nearby mountain peak. This mirror reflects sunlight into the town square, providing much-needed light and warmth during the long winter. The project, a testament to human ingenuity and community spirit, has since inspired similar initiatives worldwide.

(www.vice.com)
Tech innovation community

NASA Visualizes Global Internal Ocean Tides

2024-12-13

NASA's Goddard Space Flight Center has released a stunning visualization of global internal ocean tides, created using satellite altimetry data and simulations. The animation showcases how internal tidal waves, generated by the interaction of underwater topography, such as the Hawaiian Ridge, and tidal energy, propagate across the ocean. While these waves have a subtle surface expression, they play a significant role in ocean mixing and circulation. The visualization also highlights other regions with strong internal tidal activity, including Tahiti, the Southwest Indian Ocean, and the Luzon Strait, offering new insights into ocean dynamics.

(svs.gsfc.nasa.gov)
Tech ocean tides data visualization

In Memoriam: Donald Bitzer, Pioneer of Computing

2024-12-13

The Computer History Museum mourns the passing of Donald L. Bitzer (1934-2024), a pioneering computer scientist. Co-inventor of the flat-panel plasma display and creator of the PLATO system—the world's earliest time-shared computer-based education system and a groundbreaking online community—Bitzer's innovations presaged many modern online features. PLATO included forums, message boards, online testing, email, chat rooms, instant messaging, and multiplayer games, laying the groundwork for the interconnected digital world we know today.

(computerhistory.org)
Tech computer history plasma display PLATO system

Mirror Bacteria Research Raises Significant Risks, Scientists Warn

2024-12-13

Synthetic biologists have achieved remarkable breakthroughs, such as creating bacteria with chemically synthesized genomes. However, two synthetic biologists recently joined other scientists in calling for a halt to research that could lead to the creation of "mirror bacteria." These bacteria are composed of the same components as natural cells but with opposite stereochemistry in all biopolymers. Because mirror bacteria might lack natural predators and evade immune systems, they pose a catastrophic risk. The article emphasizes that while scientific research should be open, certain research, like mirror bacteria research, is too risky given the potential for devastating consequences. Therefore, it should be stopped.

(www.the-scientist.com)
Tech synthetic biology mirror bacteria biosafety

MIT Develops Noninvasive Imaging Method for Deeper Tissue Penetration

2024-12-13

MIT researchers have developed a novel noninvasive imaging technique that more than doubles the depth limit of metabolic imaging. Using high-powered lasers and a specialized fiber shaper, the method minimizes light scattering, allowing for clearer and faster imaging of living tissue. This label-free approach avoids tissue preprocessing, providing a more natural representation of cellular structures and functions. The increased depth penetration and speed promise significant advancements in cancer research, tissue engineering, drug discovery, and immunology.

(news.mit.edu)
Tech biomedical imaging laser technology in vivo imaging

Transformer Shortage Crisis: Can New Engineering Solve It?

2024-12-13

A global transformer shortage is delaying renewable energy projects, new home construction, and grid upgrades. The crisis stems from surging electricity demand and strained material supply chains. The article explores solutions, including redesigning transformers to use different materials, extending their lifespan, and creating more standardized, easier-to-manufacture designs. Researchers are also exploring new solid-state transformers for improved efficiency and reliability. While these new technologies are currently more expensive, their potential for enhancing grid resilience and adapting to future energy needs is significant, driving the power industry to accelerate R&D and investment to address this critical shortage.

(spectrum.ieee.org)
2
Tech transformer shortage power grid renewable energy

IBM's Executive Terminal: A Forgotten Chapter in Computing History

2024-12-13

A recently discovered 1968 videotape reveals IBM's previously unknown "Executive Terminal" system. Unlike Engelbart's "Mother of All Demos," which emphasized collaboration, this system created an information "war room" for top IBM executives. Executives used modified television sets to query information specialists, who then compiled information from various terminals and resources, presenting it visually to the executives. This showcases an alternative application of early computing technology within a hierarchical organization, contrasting sharply with the collaborative approach of the "Mother of All Demos." Together, they offer a fascinating glimpse into the early development of computing.

(spectrum.ieee.org)
3
Tech Executive Terminal Computing History

New Study Pinpoints Neanderthal Interbreeding with Modern Humans

2024-12-13

A new analysis of ancient DNA from modern humans in Europe and Asia has precisely determined the timeframe of Neanderthal interbreeding with Homo sapiens. The interbreeding began approximately 50,500 years ago and lasted for about 7,000 years, until Neanderthals began to disappear. This research, using 58 ancient genomes and present-day human genomes, revealed an average interbreeding date of around 47,000 years ago, consistent with archeological evidence. The study also found that East Asians possess about 20% more Neanderthal genes than Europeans and West Asians, potentially due to the presence of mixed genes when modern humans migrated eastward around 47,000 years ago. The findings offer a more complete picture of past human migrations and gene flow, and shed light on the impact of Neanderthal genes on modern human health.

(news.berkeley.edu)
Tech Neanderthals Homo sapiens Gene flow

Microsoft's Recall Feature Leaks Sensitive Information Despite Security Filters

2024-12-12

Microsoft's Recall feature, designed to record computer activity, has a flawed 'sensitive information filter'. Tests revealed it failed to prevent screenshots containing credit card numbers, social security numbers, and other sensitive data from being saved. While Microsoft promises improvements, the current security vulnerability raises concerns. The AI-powered filter struggles to reliably identify sensitive information, posing a significant security risk.

(www.tomshardware.com)
Tech security vulnerability

Qubes OS Unveils Secure PDF Conversion Tool

2024-12-12

The Qubes OS team has developed a novel security mechanism for converting untrusted PDFs into trusted ones. Leveraging Qubes' Disposable VMs, the process isolates PDF parsing within a secure container. The PDF is converted to a simple RGB image representation, then back to a PDF. This approach effectively mitigates attacks from malicious PDFs; even if parsing fails, the resulting PDF will only be a corrupted image, posing no system threat. This innovation significantly enhances Qubes OS security, allowing users to handle PDFs from the web or email more safely.

(blog.invisiblethings.org)
Tech secure PDF conversion disposable VMs

Google Unveils Android XR: A New Platform for Headsets and Glasses

2024-12-12

Google, in partnership with Samsung and Qualcomm, announced Android XR, a platform designed to extend reality for exploration, connection, and creation. Leveraging AI advancements, Android XR enables headsets and glasses to understand user intent and context, facilitating more natural interactions. The first device, codenamed Project Moohan and built by Samsung, will launch next year and features integration with Gemini AI, pre-installed apps like YouTube and Google TV, and seamless transitions between virtual and real environments. Future plans include support for glasses offering everyday assistance.

(blog.google)
Tech Extended Reality Artificial Intelligence
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