Wireless Gene Expression Control: Nanoparticles Enable a New Era of Precision Medicine

Researchers at ETH Zurich have developed a novel method for the electromagnetic wireless control of transgene expression in mammals using nanoparticles. The approach employs magnetic fields to stimulate multiferroic nanoparticles (cobalt ferrite and bismuth ferrite), generating biosafe reactive oxygen species (ROS) that activate the cellular KEAP1/NRF2 pathway, precisely controlling the expression of therapeutic proteins like insulin. Successfully tested on a diabetic mouse model, this technology allows for remote and dynamic therapy adjustment without injections or implants. Promising applications include oncology, neurology, and regenerative medicine, potentially revolutionizing precision medicine.