Novel Link Between Cell Nutrition and Identity Could Improve Immunotherapies

Scientists at the Salk Institute have discovered a nutritional switch from acetate to citrate is key in determining T cell fate, shifting them from active effector cells to exhausted ones. Published in Science, the findings reveal that different nutrients alter a cell's gene expression, function, and identity. This groundbreaking research offers new therapeutic targets for immunotherapies, potentially keeping T cells active against chronic diseases. The discovery highlights a direct link between cellular function and nutrition, opening new avenues for treating chronic illness.