Ketamine's Neurotoxicity: The Dark Side of Recreational Use

This article explores the neurotoxic effects of ketamine, particularly from recreational use. High-dose ketamine use leads to significant brain damage, resembling multiple sclerosis (white matter lesions) and Alzheimer's disease (grey matter atrophy) after prolonged use. Even therapeutic doses show tolerance and potential neurotoxicity. The author shares personal experiences highlighting the risks of ketamine abuse, emphasizing the need to weigh risks and benefits when considering it for treating treatment-resistant depression, acknowledging the damaging effects of untreated depression itself.