Zebrafish Protein Awakens Dormant Genes for Heart Repair

2025-01-03

Researchers at the Hubrecht Institute have repaired damaged mouse hearts using a zebrafish protein. They discovered that the protein Hmga1 is key to zebrafish heart regeneration and, in mice, activated dormant repair genes, restoring heart function without side effects. This breakthrough, published in Nature Cardiovascular Research, represents a significant step towards regenerative therapies for heart failure. The team compared zebrafish and mammalian hearts, finding Hmga1 removes 'roadblocks' on chromatin, activating dormant genes. In mice, Hmga1 stimulated heart muscle cell growth, significantly improving heart function, only in the damaged area. The study lays the groundwork for human heart regeneration therapies.

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