HORNET: A Revolutionary RNA Structure Visualization Method
2025-01-05
Researchers at the National Cancer Institute have developed HORNET, a novel method for characterizing the 3D topological structures of large and flexible RNA molecules. Combining atomic force microscopy (AFM), deep neural networks, and unsupervised machine learning, HORNET captures individual RNA conformers under physiological conditions. This overcomes limitations of traditional methods in analyzing large, flexible, heterogeneous RNAs, representing a breakthrough for RNA structural biology with profound implications for clinical, pharmaceutical, and biotechnological applications.
(phys.org)