Human Genome's Unexpected Resilience: CRISPR Reveals Tolerance to Structural Changes
2025-02-19
Scientists have achieved the most complex engineering of human cell lines ever, revealing that our genomes are far more resilient to significant structural changes than previously thought. Using CRISPR prime editing, researchers created multiple versions of human genomes with various structural alterations and analyzed their effects on cell survival. The study, published in Science, demonstrates that substantial genomic changes, including large deletions, are tolerated as long as essential genes remain intact. This groundbreaking research opens doors to understanding and predicting the role of structural variation in disease, paving the way for new therapeutic and bioengineering approaches.
(phys.org)