Human Gene Segment Boosts Mouse Brain Size by 6.5%

2025-05-18
Human Gene Segment Boosts Mouse Brain Size by 6.5%

A study published in Nature reveals that inserting a human-specific genetic segment into mice increases their brain size by 6.5%. This segment, by boosting the production of neural cells, expands the outer layer of the mouse brain. This finding could partially explain why human brains are significantly larger than those of our primate relatives. Researchers focused on a human accelerated region (HAR) called HARE5, finding it enhances the expression of the Fzd8 gene, promoting neural cell development and growth. This research provides new insights into human brain evolution.