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DHEA-S Hormone Linked to Shorter Lifespan in Men, Not Women: A Genetic Study

2025-06-23

DHEA-S Hormone Linked to Shorter Lifespan in Men, Not Women: A Genetic Study

A new genetic study suggests higher levels of dehydroepiandrosterone sulfate (DHEA-S) are associated with shorter lifespans in men, but not women. Researchers used Mendelian randomization, analyzing genetic data from large European cohorts to minimize confounding factors. The study found that genetically higher DHEA-S increased blood pressure and reduced lifespan in men, but not women. This raises questions about the labeling and over-the-counter availability of DHEA in the United States.

(medicalxpress.com)

Tech genetic study

Artificial Sweetener Erythritol May Impair Brain Blood Vessel Health

2025-06-13

Artificial Sweetener Erythritol May Impair Brain Blood Vessel Health

Researchers at the University of Colorado Boulder have found that the artificial sweetener erythritol may harm essential cellular functions maintaining brain blood vessel health. Erythritol was shown to increase oxidative stress, disrupt nitric oxide signaling, increase vasoconstrictive peptide production, and decrease clot-dissolving capacity in human brain microvascular endothelial cells. While popular in low-calorie foods due to its sweetness and negligible impact on blood sugar, epidemiological studies have linked higher erythritol levels to increased cardiovascular and cerebrovascular events. This new in vitro study provides a cellular mechanism for this association, showing adverse effects on brain endothelial cell function and potentially increasing stroke risk. Further long-term and in vivo research is recommended to clarify the cerebrovascular consequences of repeated erythritol consumption.

(medicalxpress.com)

Tech erythritol brain health stroke risk

Social Media Use Fuels Depression in Preteens: A Longitudinal Study

2025-06-11

Social Media Use Fuels Depression in Preteens: A Longitudinal Study

A three-year longitudinal study of nearly 12,000 children aged 9-10 reveals a significant link between increased social media use and worsening depressive symptoms in preteens. The research, published in JAMA Network Open, shows that increased social media use leads to increased depressive symptoms, not the other way around. On average, children's daily social media use rose from 7 to 73 minutes over three years, coinciding with a 35% increase in depressive symptoms. Researchers point to cyberbullying and sleep disruption as potential contributing factors. The study highlights the importance of fostering healthy digital habits, suggesting open conversations between parents and children and establishing screen-free times.

(medicalxpress.com)

AI teen mental health

Lightweight Wearable Chip for Real-Time Heart Attack Detection

2025-05-11

Lightweight Wearable Chip for Real-Time Heart Attack Detection

Researchers at the University of Mississippi have developed a lightweight, energy-efficient chip implantable in wearables for real-time heart attack detection. Using AI and advanced mathematics, the chip analyzes ECGs to identify heart attacks with 92.4% accuracy, twice as fast as traditional methods. Its design allows integration into devices like smartwatches, potentially saving crucial time in diagnosis and treatment, reducing the risk of permanent damage. Future applications could extend to detecting other conditions like seizures and dementia.

(medicalxpress.com)

Tech Heart Attack Detection

Aging Stem Cells: The Culprit Behind Middle-Aged Spread?

2025-05-02

Aging Stem Cells: The Culprit Behind Middle-Aged Spread?

New research unveils the cellular mechanism behind age-related abdominal fat accumulation. Scientists discovered that aging triggers the emergence of a new type of adult stem cell, called committed preadipocytes (CP-As), within white adipose tissue (WAT). These CP-As actively generate new fat cells, especially in the abdomen, with their activity significantly increasing in middle age. The leukemia inhibitory factor receptor (LIFR) signaling pathway plays a crucial role in this process. This finding offers a novel therapeutic target for preventing belly fat and extending healthy lifespan.

(medicalxpress.com)

Tech adipocytes fat accumulation

Home Washing Machines Fail to Disinfect Healthcare Uniforms, Spreading Antibiotic Resistance

2025-04-30

Home Washing Machines Fail to Disinfect Healthcare Uniforms, Spreading Antibiotic Resistance

A new study in PLOS One reveals that many home washing machines fail to effectively remove antibiotic-resistant bacteria from healthcare workers' uniforms, potentially contributing to hospital-acquired infections and antibiotic resistance. Researchers tested six home washing machine models, finding that half failed to disinfect clothing on a rapid cycle, and a third failed to adequately clean on a standard cycle. Potentially pathogenic bacteria and antibiotic resistance genes were also found inside washing machines. The findings suggest a need to revise laundry guidelines for healthcare workers or utilize on-site industrial laundry machines to improve patient safety and control the spread of antibiotic-resistant pathogens.

(medicalxpress.com)

Tech hospital-acquired infections laundry

Plastic Chemicals Linked to Hundreds of Thousands of Heart Disease Deaths Globally

2025-04-29

Plastic Chemicals Linked to Hundreds of Thousands of Heart Disease Deaths Globally

Daily exposure to phthalates, chemicals used in many plastics, is linked to over 365,000 heart disease deaths globally in 2018, a new study reveals. Africa, South Asia, and the Middle East were disproportionately affected, accounting for roughly half the deaths. The study, focusing on DEHP, a phthalate used to soften plastics, estimates its exposure contributed to more than 10% of global heart disease deaths in the 55-64 age group. Researchers urge stricter global regulations to reduce exposure to these harmful chemicals.

(medicalxpress.com)

Tech phthalates heart disease plastics

Late-Night Workouts? New Study Links Intense Exercise Before Bed to Sleep Disruption

2025-04-25

Late-Night Workouts? New Study Links Intense Exercise Before Bed to Sleep Disruption

A large-scale study involving 14,689 participants reveals a significant link between strenuous exercise within four hours of bedtime and impaired sleep quality. Participants experienced delayed sleep onset, shorter sleep duration, increased resting heart rate, and reduced heart rate variability after intense workouts close to sleep. The research, published in Nature Communications, recommends ending exercise at least four hours before bed for optimal sleep health. If exercising within this window, low-intensity activities are suggested to minimize disruption. This study provides crucial insight into the impact of exercise timing on sleep and highlights the importance of considering intensity and scheduling for better sleep.

(medicalxpress.com)

Health

Palatable Elemental Diet Shows Promise in Treating Gut Microbial Overgrowth

2025-04-24

Palatable Elemental Diet Shows Promise in Treating Gut Microbial Overgrowth

Cedars-Sinai researchers have developed mBiota Elemental, a palatable elemental diet (PED) that effectively reduces key gut microbiome taxa and improves symptoms in patients with small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO). A clinical trial showed normalized breath tests and symptom relief in most participants, with no serious adverse events. The improved palatability of this PED addresses a major limitation of previous elemental diets, leading to high adherence rates. This non-antibiotic approach offers a potential new treatment option for SIBO and IMO.

(medicalxpress.com)

Tech Gut Microbiome Elemental Diet

Immune Molecule IL-17: The Secret Driver of Anxiety and Sociability

2025-04-14

Immune Molecule IL-17: The Secret Driver of Anxiety and Sociability

Research from MIT and Harvard Medical School reveals that the immune molecule IL-17, acting on the amygdala and somatosensory cortex, respectively induces anxiety and promotes social behavior. This study highlights the close interplay between the immune and nervous systems, suggesting IL-17 may have originally evolved as a neuromodulator before being co-opted by the immune system to promote inflammation. The findings offer a novel therapeutic approach for neurological conditions like autism or depression, potentially influencing brain function by targeting the immune system.

(medicalxpress.com)

AI immune system nervous system

Hungry? Your Brain Ignores Nutritional Info!

2025-04-13

Hungry? Your Brain Ignores Nutritional Info!

New research reveals that hunger shifts attention towards the tastiness of food, causing people to overlook nutritional information—a key factor in poor dietary choices. Using eye-tracking and computational modeling, scientists found that hunger amplifies the reward associated with calorie-dense foods, diminishing the importance of nutritional labels. This suggests that simply displaying nutritional labels might be insufficient to combat hunger-driven unhealthy eating. Interventions should focus on making health information more visually prominent or directing attention towards it.

(medicalxpress.com)

Tech hunger food choice nutrition

High-Dose Vitamin D Significantly Reduces Disease Activity in Early MS Onset: Clinical Trial

2025-03-25

High-Dose Vitamin D Significantly Reduces Disease Activity in Early MS Onset: Clinical Trial

A French study published in JAMA found that 100,000 IU of oral cholecalciferol every two weeks significantly reduced disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosis. The randomized controlled trial of 316 participants showed a significantly lower rate of disease activity in the high-dose vitamin D group compared to the placebo group. This research supports vitamin D as a potentially inexpensive and well-tolerated treatment option, especially in areas with limited access to standard therapies.

(medicalxpress.com)

Tech Multiple Sclerosis Vitamin D Clinical Trial

Groundbreaking: iPS Cell Therapy Restores Movement in Spinal Cord Injury Patients

2025-03-24

Groundbreaking: iPS Cell Therapy Restores Movement in Spinal Cord Injury Patients

Japanese scientists have achieved a breakthrough in the world's first clinical trial using induced pluripotent stem cells (iPS cells) to treat spinal cord injuries. Two out of four patients showed significant improvement in motor function, with one now able to stand unaided and begin walking practice. The study primarily focused on safety, and future clinical trials are hoped to bring this promising treatment to more patients.

(medicalxpress.com)

Tech iPS cells stem cell therapy

AI Discovers Novel Weight-Loss Molecule Rivaling Ozempic, Without Side Effects

2025-03-07

AI Discovers Novel Weight-Loss Molecule Rivaling Ozempic, Without Side Effects

Stanford Medicine researchers, using an AI algorithm, have identified a naturally occurring molecule, BRP, that rivals semaglutide (Ozempic) in suppressing appetite and reducing body weight. Importantly, animal testing showed BRP avoids side effects like nausea, constipation, and muscle loss. BRP acts through a distinct but similar metabolic pathway, targeting the hypothalamus to control appetite. A company has been formed to launch human clinical trials. This breakthrough relied on AI to sift through thousands of proteins, offering a promising new avenue for obesity treatment.

(medicalxpress.com)

AI weight loss biomedicine

Mice Exhibit Paramedic-Like Behavior: Neural Mechanisms Unveiled

2025-03-05

Mice Exhibit Paramedic-Like Behavior: Neural Mechanisms Unveiled

UCLA researchers have discovered that mice display prosocial behavior towards unresponsive conspecifics, characterized by intense head-directed grooming. This behavior is driven by an amygdala-regulated response. Experiments showed mice differentiating between sedated and stressed peers, grooming the head of sedated mice and the body of stressed ones. Neural recordings and optogenetic manipulation pinpointed the medial amygdala (MeA) as crucial; silencing MeA GABAergic neurons suppressed head grooming while activation enhanced it. This research illuminates the neural basis of prosocial behavior in mice, offering insights into broader animal social behaviors. This falls under the Tech category.

(medicalxpress.com)

Tech prosocial behavior

Turning Therapeutic Bleeding into Lifesaving Donations: The Australian Hemochromatosis Story

2025-03-01

Turning Therapeutic Bleeding into Lifesaving Donations: The Australian Hemochromatosis Story

Australian research reveals that blood regularly discarded from individuals with hemochromatosis, an iron overload disorder, can be used to save lives. Australian Red Cross Lifeblood is the first globally to allow these individuals to donate both blood and plasma. A study shows that reframing these patients as donors instead of patients, along with increased awareness, could significantly boost blood supplies and save countless lives. Currently, 15,000 Australians with hemochromatosis make 37,000 donations annually, and Australia is the first country to allow plasma donations from this group.

(medicalxpress.com)

Tech hemochromatosis blood donation plasma donation

Daily Omega-3s May Slow Biological Aging

2025-02-09

Daily Omega-3s May Slow Biological Aging

A three-year clinical trial involving over 700 older adults suggests that consuming one gram of omega-3 fatty acids daily may slow the rate of biological aging. Researchers used epigenetic clocks to measure aging and found omega-3 consumption moderately slowed aging by up to four months. Combining omega-3 with vitamin D and exercise showed even greater benefits, significantly impacting cancer risk and frailty. Published in Nature Aging, this study highlights omega-3's potential as an anti-aging intervention.

(medicalxpress.com)

Tech Aging Health

Heavy Social Media Use Linked to Higher Irritability

2025-01-23

Heavy Social Media Use Linked to Higher Irritability

A study published in JAMA Network Open found a correlation between frequent social media use and higher levels of irritability among US adults. The research, involving 42,597 participants, revealed that even after accounting for anxiety and depression, frequent use, especially among active posters, was associated with increased irritability scores. A dose-response relationship was observed, with TikTok users exhibiting the largest increase in irritability when posting multiple times daily. Political engagement also correlated with higher irritability levels. The findings suggest a potential feedback loop between social media use and irritability.

(medicalxpress.com)

Tech irritability

Commercial Tea Bags Release Millions of Microplastics, Entering Human Intestinal Cells

2024-12-23

Commercial Tea Bags Release Millions of Microplastics, Entering Human Intestinal Cells

Research from the Autonomous University of Barcelona reveals that commercial tea bags release millions of microplastics and nanoplastics during brewing. The study, published in Chemosphere, shows for the first time that these particles can be absorbed by human intestinal cells, entering the bloodstream and potentially spreading throughout the body. Analysis of tea bags made from nylon-6, polypropylene, and cellulose revealed polypropylene released the highest number of particles—approximately 1.2 billion per milliliter. The microplastics were even observed entering the cell nucleus. The findings highlight the need for further research into the long-term health effects of chronic exposure and for regulations to mitigate microplastic contamination from food packaging.

(medicalxpress.com)

Tech microplastic pollution tea bags human health