Programmable Embryo Models Created Using CRISPR
2025-03-23
Scientists at UC Santa Cruz have engineered cellular models of embryos without using actual embryos, mimicking the first few days after fertilization. Using CRISPR-based gene editing, they coaxed mouse stem cells into self-organizing structures called embryoids, replicating key stages of early embryonic development. This allows for the study of gene function in early development and the mechanisms of developmental disorders. Published in Cell Stem Cell, this research offers a new avenue for understanding human infertility and improving fertility treatments.
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