Pitt Study Upends Decades-Old Assumptions About Brain Plasticity
2025-06-05
A groundbreaking Pitt study challenges the long-held belief that the brain uses a single mechanism for plasticity. Researchers found that distinct transmission sites are responsible for different types of plasticity, specifically spontaneous and evoked transmissions. Published in Science Advances, the study reveals that the brain uses separate sites with unique developmental timelines and regulatory rules. This dual system maintains stability while allowing flexibility for learning and adaptation. The findings have significant implications for understanding neurological and psychiatric conditions like autism and Alzheimer's disease, offering a new avenue for research into synaptic signaling dysregulation.
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