Disruptive Theory: Venous Backflow May Be the Root Cause of Prostate Diseases
2025-04-26
This article explores a disruptive theory proposed by Gat and Goren: the main cause of male prostate diseases (benign prostatic hyperplasia and prostate cancer), as well as male infertility, may be venous backflow due to incompetent spermatic vein valves. The backflowing blood, rich in testosterone, leads to abnormal prostate growth. This theory offers an elegant mechanical explanation, but its pressure and hemodynamics aspects remain controversial. While the theory hasn't gained widespread acceptance, some research supports its claims and offers a simple screening and minimally invasive surgical approach.