Metformin's Secret Revealed: Mitochondria Hold the Key
2024-12-18
A new study unveils the precise mechanism of action for metformin, a widely used drug for Type 2 diabetes. Researchers discovered that metformin lowers blood sugar by interfering with mitochondria, the cell's powerhouses. Specifically, it blocks mitochondrial complex I, a crucial part of the cell's energy-producing machinery. This research, published in Science Advances, used genetically engineered mice to demonstrate that metformin targets disease-contributing cells without significantly harming healthy ones. This provides a deeper understanding of how this 'wonder drug' works.