Two Waves of Aging: How Midlife Biomolecular Shifts Accelerate Decline
2025-01-12
Challenging the linear view of aging, a new study reveals a two-wave model: around age 40 and 60. The first wave involves disruptions in lipid metabolism, chronic inflammation, and gut microbiome, leading to tissue dysfunction. The second wave features immune senescence, insulin resistance, and declining kidney function, further accelerating age-related decline. The study highlights the potential of precision interventions, such as rapamycin and modulating the GH/IGF-1 pathway, to recalibrate these developmental processes and extend healthspan.