Concussions May Reactivate Brain Virus, Increasing Dementia Risk: Organoid Study
2025-02-01
A new study using brain organoids—3D clumps of neuronal tissue derived from human stem cells—has modeled the effects of concussions on the brain. Researchers found that repeated head impacts may contribute to Alzheimer's and other dementias by reactivating latent herpes simplex virus type 1 (HSV-1). In organoids infected with HSV-1, repeated jolts reactivated the virus, leading to increased beta-amyloid protein and neuroinflammation, hallmarks of Alzheimer's. This research provides new insights into the link between traumatic brain injury and dementia, potentially opening avenues for preventative and therapeutic strategies.