Cancer Metabolism Research: A Novel Perspective on Fat and Brown Adipose Tissue
Recent breakthroughs in cancer metabolism research have revealed the dependence of tumor cells on glucose and lipid metabolism. Researchers are exploring ways to target metabolic pathways in cancer cells, such as inhibiting hexokinase-2, glucose transporter 1, and fatty acid synthase. Studies also investigate metabolic inhibitors like 6-aminonicotinamide and etomoxir to suppress tumor growth. Furthermore, research focuses on the role of brown adipose tissue in tumor suppression, showing that cold exposure and activation of the PRDM16 pathway can promote brown fat generation, thus inhibiting tumor growth. These studies offer promising avenues for developing novel cancer therapies, particularly targeted therapies based on metabolic regulation.