The Reproducibility Crisis: How Genomic Mutations in Model Organisms Are Skewing Results
2025-05-15
A new study reveals that the genomes of laboratory animal models accumulate mutations over time, a significant contributor to the reproducibility crisis in scientific research. Researchers found that common model animals like mice acquire new mutations each generation, potentially altering gene regulation and impacting experimental outcomes. While some labs attempt to mitigate this by cryopreserving embryos, it's not a complete solution. To improve reproducibility, scientists need more frequent genomic sequencing of model organisms and a better understanding of gene regulation differences to better control experimental variables.