Migraine Breakthrough: From Trepanation to Targeted Therapies
2025-02-18
For millennia, migraine treatment ranged from ancient Egyptian clay crocodiles to 17th-century trepanation. Now, deeper understanding of brain mechanisms, particularly the development of CGRP-targeting drugs like gepants, has redefined migraine as a treatable condition. While not a panacea, the success of CGRP inhibitors marks a new era in migraine research. Future breakthroughs may involve further investigation of brain regions like the hypothalamus to develop more effective therapies, offering hope to millions suffering from this debilitating condition.