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New Class of Virus-like Entities Found in Human Gut

2024-12-30
New Class of Virus-like Entities Found in Human Gut

Researchers have discovered a completely new class of virus-like objects in the human digestive system, dubbed 'Obelisks'. These RNA structures, approximately 1,000 nucleotides long, are unlike any known viruses and may represent an entirely new biological entity, potentially bridging the evolutionary gap between simple genetic molecules and complex viruses. Found in human microbiomes, Obelisks code for a novel protein called 'Oblins', but their impact on host cells and their transmission mechanism remain unknown. This discovery opens up exciting new avenues for life science research.

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(www.sciencealert.com)
AI virus microbiome

Railgun Labs Unveils High-Performance Unicode Algorithm Library: Unicorn

2024-12-15

Railgun Labs has released Unicorn, a high-velocity Unicode algorithm library known for its speed, embeddability, cross-platform compatibility, and security. Unicorn supports numerous Unicode algorithms, including normalization, case conversion, collation, and segmentation, and provides decoders, encoders, and validators for UTF-8, UTF-16, and UTF-32 encodings. The library is fully customizable and extensively tested for accuracy and reliability. It's MISRA C:2012 compliant and largely thread-safe.

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(railgunlabs.com)
Development Unicode algorithms software library high-performance

The Extraordinary Life of Potoooooooo: A Racing Legend

2025-01-16
The Extraordinary Life of Potoooooooo: A Racing Legend

Potoooooooo, a chestnut thoroughbred with a legendary status, is renowned for his unusual name and spectacular racing career. He won over 25 races, his name, a humorous misspelling of "Potatoes," adding to his colorful story. After retirement, Potoooooooo became a significant sire, his offspring including multiple Epsom Derby winners. His genetic legacy continues to shape thoroughbred racing to this day.

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(en.wikipedia.org)
Misc horse racing thoroughbred pedigree

T2 SDE: Major Update for Cross-Architecture OS Development Environment

2024-12-24

T2 SDE is a low-code, ultra-portable package manager and Linux distribution that enables fully automated, reproducible, cross-compilation of custom operating systems across architectures (ARM, x86-64, etc.). The latest release, T2 24.12, boasts 37 pre-compiled ISO images supporting 25 CPU architectures and includes numerous packages like LibreOffice and OpenJDK. It even has proof-of-concept support for the Nintendo Wii U. T2 continues to improve, with a commitment to supporting IA-64 Itanium, enhancing security features like full-disk encryption, and boosting performance through features like hardware video encoding and decoding.

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(t2sde.org)
Development Cross-Compilation Package Manager

Confronting Shipwreck: Maritime Disasters and Ecological Collapse in Literature

2024-12-19
Confronting Shipwreck: Maritime Disasters and Ecological Collapse in Literature

A nature writer battling a debilitating genetic kidney disease finds solace and healing in reading about maritime disasters amidst the backdrop of ecological collapse. The article lists ten books exploring shipwrecks and environmental devastation, ranging from Melville's *Moby-Dick* to Grann's *The Wager*. These narratives not only depict the harrowing events but also delve into humanity's relationship with nature, resilience, and the spectrum of human behavior during crisis. The author advocates for confronting adversity head-on and drawing strength from the experience as a vital step in overcoming personal and ecological challenges.

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(lithub.com)
Misc maritime literature ecological collapse healing

PubPeer Review: TRF2-S Protein Regulates Axonal mRNA Transport

2025-01-16

A PubPeer post discusses a research article on TRF2-S, a novel RNA- and FMRP-binding protein crucial for regulating axonal mRNA transport and presynaptic plasticity. Published in Nature Communications, the study reveals how TRF2-S influences neuronal growth and function by impacting mRNA trafficking and local translation. This research sheds light on neural mechanisms and potentially offers new avenues for neurological disease treatment.

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(pubpeer.com)
Tech Neuroscience RNA-binding protein Axonal transport

Metformin's Secret Revealed: Mitochondria Hold the Key

2024-12-18
Metformin's Secret Revealed: Mitochondria Hold the Key

A new study unveils the precise mechanism of action for metformin, a widely used drug for Type 2 diabetes. Researchers discovered that metformin lowers blood sugar by interfering with mitochondria, the cell's powerhouses. Specifically, it blocks mitochondrial complex I, a crucial part of the cell's energy-producing machinery. This research, published in Science Advances, used genetically engineered mice to demonstrate that metformin targets disease-contributing cells without significantly harming healthy ones. This provides a deeper understanding of how this 'wonder drug' works.

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(news.northwestern.edu)
Tech metformin mitochondria diabetes

Apple Accuses Meta of Unreasonable Interoperability Requests Under EU's DMA

2024-12-19
Apple Accuses Meta of Unreasonable Interoperability Requests Under EU's DMA

Apple has accused Meta of making 15 interoperability requests under the European Union's Digital Markets Act (DMA), more than any other company. Apple claims Meta's requests, which could compromise user security and privacy, seek access to extensive user data including messages, emails, call logs, app usage, photos, files, calendar events, and passwords. Apple argues these requests are unreasonable, emphasizing the importance of iOS and iPadOS integrity and the potential infeasibility of creating effective interoperability solutions. The European Commission is consulting on the matter and may adjust measures based on feedback.

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(www.macrumors.com)
Tech Digital Markets Act

Hackers Reveal Vulnerability in Europe's Remotely Controlled Power Grid

2024-12-29
Hackers Reveal Vulnerability in Europe's Remotely Controlled Power Grid

A significant portion of Europe's renewable energy production is remotely controlled via longwave radio. While designed to stabilize the grid, this system, using unencrypted and unauthenticated Versacom and Semagyr protocols, is vulnerable to abuse. Researchers analyzed these protocols and demonstrated how vulnerabilities could be exploited to remotely control streetlights, power plants, and potentially cause large-scale blackouts. They also showcased the possibility of using this vulnerability to create a city-wide light art installation.

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(media.ccc.de)
Tech grid security remote control

Microsoft Research Unveils F*: A Proof-Oriented Programming Language

2024-12-25

F* (pronounced F star) is a general-purpose, proof-oriented programming language supporting both purely functional and effectful programming. Combining the expressive power of dependent types with automated proof generation via SMT solving and tactic-based interactive theorem proving, F* defaults to compiling to OCaml. However, it can also be extracted to F#, C, or WebAssembly using KaRaMeL, or to assembly using Vale. Developed and actively maintained by Microsoft Research, Inria, and the community, the open-source F* is used in various projects, including those within Mozilla Firefox and the Linux kernel, showcasing its applications in security, cryptography, and systems development.

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(fstar-lang.org)
Development proof-oriented programming dependent types

LLMs Conquered: A Graveyard of AI Benchmarks

2025-01-06

Killedbyllm.com is a fascinating website documenting the rapid progress of Large Language Models (LLMs). It lists numerous benchmarks, from early reading comprehension tests to complex mathematical reasoning challenges, that have been surpassed by models like GPT-4 and LLaMa. The site serves as a testament to the breakneck speed of AI advancement, showcasing how previously insurmountable challenges have fallen to LLMs and prompting reflection on the future of AI.

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(r0bk.github.io)
AI Benchmarks

NASA JPL Horizons: A Powerful Tool for Exploring the Solar System

2025-01-03

NASA's Jet Propulsion Laboratory's Horizons system is a powerful online service providing precise orbital data and ephemerides for solar system objects. It offers multiple access methods including a web interface, command-line interface, email, and an API. Users can query information on asteroids, comets, planets, satellites, and more, and perform orbital calculations and visualizations. Horizons is a powerful tool for astronomers, aerospace engineers, and space enthusiasts exploring the mysteries of our solar system.

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(ssd.jpl.nasa.gov)
Tech Solar System Data

Fast Food vs. Home-Cooked Software: A Developer's Dilemma

2025-01-17

This article explores two contrasting approaches to software development: fast food and home-cooked. Fast food software uses agile sprints, prioritizing rapid iteration over long-term maintainability. Home-cooked software emphasizes upfront design, resulting in lean, stable code, but with longer development cycles. The author criticizes the prevalent fast food approach, highlighting its creation of massive technical debt and poor user experiences. A call for a return to a more quality-focused, maintainable approach is made.

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(ownerofhappy.org)
Development

Common Lisp Time Handling: The LOCAL-TIME Solution

2025-01-01

This paper delves into the complexities of time handling in Common Lisp and presents the author's solution: the LOCAL-TIME library. It traces the evolution of human time representation, from imprecise, context-dependent notations to precise scientific ones, highlighting the chaos introduced by political factors like daylight saving time. LOCAL-TIME uses an efficient fixnum-based representation, integrates world timezone data, and handles various time calculations and format conversions, thereby avoiding errors stemming from imprecise time representation—like the infamous Y2K problem.

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(naggum.no)
Development Time Handling

Artie (YC) is Hiring a Founding Engineer for Distributed Systems

2025-01-16
Artie (YC) is Hiring a Founding Engineer for Distributed Systems

Artie, a Y Combinator-backed startup, is seeking a Founding Engineer focused on distributed systems. Artie offers a real-time database replication solution leveraging Kafka and CDC, processing over 10 billion rows monthly. The ideal candidate possesses strong computer science fundamentals, thrives in a multi-faceted role, and has experience with asynchronous systems and technologies like gRPC, Kafka, and Kubernetes (though not strictly required). Go proficiency is preferred but not mandatory. This challenging role offers the opportunity to shape the next generation data platform, aiming for zero data latency while maintaining ease of use and scalability.

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(www.ycombinator.com)
Development data engineering

The Impossibility Theorem of Clustering: Why Perfect Algorithms Don't Exist

2024-12-26
The Impossibility Theorem of Clustering: Why Perfect Algorithms Don't Exist

This article explores the 'impossible triangle' problem in clustering algorithms. Drawing a parallel to the CAP theorem, the author argues that every clustering algorithm must sacrifice one of three desirable properties: scale invariance, richness, and consistency. The article defines each property and illustrates how algorithms like k-means compromise on one to achieve the others. The conclusion emphasizes that developers should choose algorithms based on the specific needs of their application, accepting that a perfect clustering algorithm is mathematically impossible.

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(blog.codingconfessions.com)
AI clustering algorithms impossibility theorem

Revisiting Barricelli's Cellular Automata: Spontaneous Generation of Life

2025-01-07

This article explores the work of Nils Aall Barricelli, who pioneered cellular automata 15 years before John Conway. Barricelli's 'symbioorganisms' model, in a finite, circular 1D space, simulates the movement and interaction of different elements through simple rules of collision elimination, positional replication, and mutation. The simulations reveal that even with simple rules, stable periodic patterns spontaneously emerge, resembling the spontaneous generation of life. The author delves into the stability of these patterns and proposes combining early universe simulations with simulations of abiogenesis to find more efficient ways to explore life's origins.

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(akkartik.name)
AI abiogenesis complex systems

Ocular AI, a YC Startup, Seeks Founding Backend Engineer

2024-12-26
Ocular AI, a YC Startup, Seeks Founding Backend Engineer

Ocular AI, a Y Combinator-backed AI startup, is hiring a Founding Backend Engineer to build backend systems for its data annotation engine. The company helps transform unstructured data into high-quality datasets for generative AI, frontier models, and computer vision. The role requires 3+ years of experience with Python/Node and Postgres for production systems, along with hands-on experience training ML models and building data pipelines. This is a high-impact role working directly with founders to shape product direction and engineering strategy. The ideal candidate enjoys working in a fast-paced, ambiguous environment.

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(www.ycombinator.com)
AI Backend Engineer

A Programmer's Lesson: Always Bundle a Proposal with a Complaint

2024-12-27
A Programmer's Lesson: Always Bundle a Proposal with a Complaint

In 1988 at Apple, a young, cocky engineer, Kent Beck, was summoned to Jean-Louis Gassée's office after sending an email complaining about a company decision. Instead of anger, Gassée challenged Beck to consider his perspective and rewrite the email as a proposal for a solution. This experience taught Beck three valuable lessons: most problems aren't as big as they seem; always include a solution with a complaint; and effective communication requires empathy. This anecdote highlights crucial workplace communication skills and the importance of understanding different viewpoints.

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(tidyfirst.substack.com)
Development workplace communication proposal empathy

Mastodon Jaw Unearthed in New York Backyard

2024-12-22
Mastodon Jaw Unearthed in New York Backyard

A New York man's gardening project took an unexpected turn when he discovered what he initially thought were baseballs, but turned out to be giant teeth. These teeth, unearthed in his upstate New York backyard, were identified as belonging to a mastodon. Subsequent excavation by the New York State Museum and SUNY Orange revealed a complete, well-preserved adult mastodon jaw, a toe bone, and a rib fragment. This is the first complete mastodon jaw found in New York in 11 years, offering invaluable insights into the Ice Age ecosystem. The fossils will be carbon-dated and analyzed, with plans to put them on public display in 2025.

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(apnews.com)
Misc mastodon fossil

Mind-blowing! AI Art Generator Midjourney Creates Hyperrealistic Images

2025-01-06

Midjourney, an AI-powered image generation tool, is creating stunning images based on text prompts. Recently, its outputs have gone viral, showcasing hyperrealism that blurs the lines between reality and AI-generated art. This has sparked intense debate about the future of AI in art, its potential to revolutionize creative processes, and concerns about its impact on human artists. Midjourney represents a significant milestone in AI technology, demonstrating the immense potential of AI in image generation.

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(www.gatesnotes.com)
AI

Asus, Samsung, and MSI Announce World's First 27-inch 4K OLED 240Hz Monitors

2025-01-02
Asus, Samsung, and MSI Announce World's First 27-inch 4K OLED 240Hz Monitors

Asus, Samsung, and MSI have jointly unveiled the world's first 27-inch 4K OLED 240Hz gaming monitors. All three utilize Samsung Display's fourth-generation QD-OLED panel, promising a longer lifespan and leveraging DisplayPort 2.1a for 4K 240Hz refresh rates without Display Stream Compression (DSC). While largely similar in specs, minor differences exist in size (Asus' is 26.5-inches), HDR support (Asus includes Dolby Vision), and warranty details. Release dates and pricing remain unannounced, but the combination of high refresh rate, high resolution, and OLED technology positions these monitors as top-tier gaming displays.

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(www.theverge.com)
Hardware OLED monitor gaming monitor

Demystifying Common Microcontroller Debug Protocols

2024-12-27
Demystifying Common Microcontroller Debug Protocols

This talk delves into common microcontroller debugging protocols like JTAG and SWD. Starting from the physical signals, it explains how these protocols work, covering common mechanisms for managing embedded processors and interacting with various microcontrollers. The presentation explores the meaning of debugging embedded software, building a list of requirements for a comfortable debugging environment, and referencing existing custom debug approaches. Examples range from FPGA cores to tiny 8-bit microcontrollers. Common abstractions like ARM's ADI and RISC-V DMI are also covered, bridging the gap between protocols and core control. Finally, it explains common tasks like flash programming, watchpoints, and single-stepping.

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(media.ccc.de)
Development Microcontroller Debugging

Testing for Thermal Issues in Advanced Packages Becomes Increasingly Challenging

2024-12-21
Testing for Thermal Issues in Advanced Packages Becomes Increasingly Challenging

The increasing complexity and heterogeneity of chip architectures, coupled with the adoption of high-performance materials, are making it significantly more difficult to identify and test for thermal issues in advanced packages. Traditional corner-based thermal testing is insufficient due to unpredictable chip-level thermal effects and varying heat distribution under different workloads. Heterogeneous integration, thinner substrates and metal layers, and diverse materials and interconnect schemes all contribute to this complexity. To address these challenges, the industry is exploring advanced thermal modeling, test structures, adaptive testing strategies, and AI to achieve more accurate thermal characterization and reliable device testing.

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(semiengineering.com)
Hardware chip testing thermal management heterogeneous integration heat dissipation chip packaging thermal testing

Ryanair Faces GDPR Complaint Over Mandatory Face Scans

2024-12-19
Ryanair Faces GDPR Complaint Over Mandatory Face Scans

The privacy advocacy group noyb filed a GDPR complaint against Ryanair for forcing users to create accounts and undergo invasive biometric verification, including face scans, during the booking process. This practice, allegedly aimed at preventing online travel agencies from bulk purchasing tickets, violates GDPR principles of data minimization, purpose limitation, and consent. Ryanair is accused of prioritizing competitive advantage over user privacy.

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(noyb.eu)
Misc biometrics

So You Want to Write Java in Neovim?

2024-12-28

This post details how to efficiently develop Java code within the Neovim editor. The author shares their positive experience using Neovim for Java at work, recommending JDTLS as the LSP server and either nvim-java or nvim-jdtls as Neovim plugins. The article thoroughly explains JDTLS configuration, including debugging and testing setups, and provides a personal configuration example featuring codelens and debugger functionality. Even if you're not a Neovim devotee, you can still learn valuable Java development techniques.

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(ptrtojoel.dev)
Development Java Development

Bluesky's Trending Topics: A Curated Overview

2025-01-23

Bluesky social media platform showcases a vibrant array of trending feeds, categorized into diverse interests such as science, pets, books, music, gaming, art, Black culture, and sports. These curated feeds, organized by keywords and hashtags, offer users streamlined access to engaging content. The platform also provides tools for users to create and manage their own thematic feeds.

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(www.bskyinfo.com)
Tech Curated Feeds

OpenAI: The Next Visa? Challenges and Risks on the Path to Monopoly

2024-12-26
OpenAI: The Next Visa? Challenges and Risks on the Path to Monopoly

The article compares OpenAI to Visa, arguing its success isn't due to superior technology but to erecting barriers through exclusive deals, government contracts, and licensing restrictions to limit competition. OpenAI attempts to build these barriers by lobbying for government regulation, restricting investors from funding competitors, and securing long-term exclusive contracts with large clients. However, this strategy faces political and competitive headwinds. Similar to Visa's past challenges, the increasing ubiquity of LLM technology threatens the core API business. Competition from Elon Musk and potential relaxation of government regulation further complicate OpenAI's efforts to maintain its dominance. Ultimately, OpenAI's future hinges on whether it can build sufficiently high barriers to entry, both technologically and legally, to avoid repeating Visa's antitrust lawsuit.

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(sherwood.news)
AI monopoly

wonderful.dev: The Developer Portfolio Platform

2025-01-12

wonderful.dev is a developer-focused online portfolio platform designed to help developers showcase their skills, track industry trends, and find ideal jobs or projects. The platform supports skill verification and integrates with WakaTime data, allowing developers to showcase their abilities with data-backed credibility, enhancing their competitiveness in the job market. Developers can create profiles, highlight verified skills and achievements, follow the latest tech trends, and discover opportunities perfectly aligned with their expertise.

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(wonderful.dev)
Development developer portfolio skill showcase job platform
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