Reforming Clinical Trials: Accelerating Drug Development and Lowering Costs

2024-12-22
Reforming Clinical Trials:  Accelerating Drug Development and Lowering Costs

A research report from the Institute for Progress (IFP) explores reform proposals for clinical trials in the US. The report highlights how lengthy and expensive clinical trials hinder medical innovation. Nine specific recommendations are proposed, including streamlining regulations, improving clinical trial databases, and adopting risk-based monitoring, aiming to accelerate new drug development and benefit more patients by increasing efficiency and reducing costs. This reflects a positive exploration of using technology (such as AI) to improve healthcare efficiency.

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Carta's Difficult Subscription Cancellation Process Sparks Outrage Among Founders

2024-12-12
Carta's Difficult Subscription Cancellation Process Sparks Outrage Among Founders

Funding management software Carta is facing criticism for its cumbersome subscription cancellation process. Several founders have taken to social media to complain about the difficulty of cancelling their subscriptions, citing mandatory meetings scheduled well after their renewal dates. While Carta attributes the issue to a temporary staffing shortage, competitors highlight their straightforward cancellation methods, involving simple clicks or emails. This controversy raises concerns about Carta's customer service and cancellation policies, underscoring the importance of careful consideration when choosing service providers.

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Century-Scale Digital Storage: A Race Against Time

2024-12-14
Century-Scale Digital Storage: A Race Against Time

This article explores the challenge of storing digital data for 100 years. From the invention of IBM's first hard drive-equipped computer, RAMAC, to the prevalence of cloud storage today, the author analyzes the advantages and disadvantages of various storage methods, including hard drives, cloud storage, removable media, and physical imprinting or printing. The article highlights the threats to long-term data preservation, such as physical damage to hardware, software updates, institutional changes, and market fluctuations. Ultimately, the author argues that the key to century-scale digital storage lies in establishing a culture that values maintenance and preservation, requiring a collective effort from all sectors of society to combat the erosion of time and safeguard humanity's digital heritage.

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TeaVM 0.11.0 Released: New WebAssembly Backend

2024-12-15

TeaVM 0.11.0 has been released, featuring a brand new WebAssembly backend. The old WebAssembly backend, while functional, lacked adoption due to insignificant performance gains and a poor developer experience. The new backend, leveraging the WebAssembly GC proposal, addresses these issues, improving interaction with browser JS APIs and reducing binary file size. While currently slightly less feature-rich than the JS backend, it already supports JSO (Java-to-JS interaction API), aiming for parity in the next release. This release also includes bug fixes in BitSet implementation and adds support for various JS APIs, such as file reading, touch events, the Popover API, and Navigator.sendBeacon.

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Development

Bruin: Build Data Pipelines with SQL and Python

2024-12-17
Bruin: Build Data Pipelines with SQL and Python

Bruin is a powerful data pipeline tool that combines data ingestion, data transformation with SQL and Python, and data quality checks into a single framework. It works with major data platforms and runs on your local machine, an EC2 instance, or GitHub Actions. Key features include data ingestion, SQL & Python transformations, data quality checks, Jinja templating, end-to-end validation, and support for multiple environments. Pipelines are easily defined using a simple pipeline.yml file.

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Development data pipeline

The Secret Spy Satellite That Helped Win the Cold War

2025-01-22
The Secret Spy Satellite That Helped Win the Cold War

In the 1970s, the rise of the Soviet Navy posed a significant threat to the US. To counter the emergence of powerful new Soviet warships, the top-secret Parcae satellite program was launched. Developed by the US Naval Research Laboratory, Parcae provided real-time location data on Soviet vessels, drastically reducing the time between signal interception and intelligence reporting to mere minutes. This near-instantaneous intelligence was crucial for military decision-making. Employing multiple satellites working in concert and advanced computer systems to process massive amounts of data, Parcae helped maintain the strategic balance during the Cold War. Its technology continues to influence modern satellite signals intelligence systems.

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XFCE 4.20 Released: Experimental Wayland Support and Numerous Improvements

2024-12-15

After nearly two years of development, XFCE 4.20 has been officially released! This version focuses on preparing the codebase for Wayland, now offering experimental Wayland support for most components, though it's still in its early stages and recommended for advanced users. XFCE 4.20 also boasts numerous new features, bug fixes, and improvements, including improved icon scaling, a performance-enhanced icon view, and an upgraded Thunar file manager. Importantly, Wayland support is incomplete, with some components and features yet to be ported.

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Development Desktop Environment

Debunking the Myth: Thomas Watson and the Five Computers

2025-01-24

The widely circulated quote attributed to IBM's Thomas Watson, "I think there is a world market for maybe five computers," is revealed to be an urban legend. This article traces the quote's origins, demonstrating it's not from 1943, but a misinterpretation of his remarks at a 1953 shareholder meeting. Watson discussed sales projections for the IBM 701, not the entire computer market. This highlights the importance of verifying online information and the spread of misinformation.

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Using eSIMs on Devices with Only Physical SIM Slots: A 9eSIM Review

2025-01-20
Using eSIMs on Devices with Only Physical SIM Slots: A 9eSIM Review

This blog post details using a 9eSIM SIM card to enable eSIM functionality on devices that only accept physical SIM cards, tested on Android and Linux. The author purchased a 9eSIM bundle including the SIM, smartcard reader, and adapter. Initial setup proved slightly tricky, requiring the SIM card to be used within its original packaging for proper reader connection. Adding, switching, and deleting eSIM profiles was straightforward using an Android app or the Linux command-line tool lpac (and its GUI, EasyLPAC). Tests were conducted with free test eSIM profiles and a paid LycaMobile eSIM, successfully achieving eSIM connectivity on a Debian Linux laptop.

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Hardware physical SIM

EHT Reveals Turbulent Accretion Flow Around M87*'s Black Hole

2025-01-25

The Event Horizon Telescope (EHT) Collaboration has released a new analysis of the supermassive black hole at the center of Messier 87 (M87*), combining observations from 2017 and 2018. The study confirms that M87*'s black hole rotational axis points away from Earth and highlights the significant role of turbulence within the accretion disk in explaining the observed shift in the ring's brightness peak. Using a vastly expanded simulation image library, the team confirmed the counter-clockwise 30-degree shift of the brightest region of the ring between 2017 and 2018. This research represents a major step forward in understanding the complex dynamics of black hole environments.

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A New Twist: Molecular Machines Loop and Twist Chromosomes

2024-12-17
A New Twist: Molecular Machines Loop and Twist Chromosomes

Scientists have discovered a new function of the molecular motors that shape our chromosomes: SMC proteins not only form long loops in DNA but also significantly twist the DNA during loop formation. Published in Science Advances, the research reveals that SMC proteins introduce a left-handed twist of 0.6 turns in each DNA loop extrusion step. This twisting action is conserved across species, observed in both human and yeast cells, highlighting its evolutionary importance. This finding enhances our understanding of chromosome structure and function and provides insights into developmental diseases like cohesinopathies.

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Stripe Investigates Unexpected DNS Error Spike: A Tale of Complex Network Troubleshooting

2024-12-12
Stripe Investigates Unexpected DNS Error Spike: A Tale of Complex Network Troubleshooting

Stripe recently experienced an unexpected spike in DNS errors. This post details how they used tools like Unbound, tcpdump, and iptables to track down the root cause. The investigation revealed that a Hadoop job analyzing network logs was performing numerous reverse DNS lookups (PTR records), leading to traffic amplification due to retries exceeding the AWS VPC resolver's limits. Stripe resolved the issue by adjusting Unbound forwarding configurations to distribute the load across individual Hadoop hosts. The case highlights the importance of robust monitoring, multi-faceted troubleshooting, and strategies for handling traffic surges in high-availability systems.

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Gource: Visualizing Your Codebase with Stunning Animations

2025-01-03
Gource: Visualizing Your Codebase with Stunning Animations

Gource is an open-source software that visualizes your version control repository history in a breathtaking animated way. The repository root is at the center, directories are branches, files are leaves, and developers become dynamic characters moving around the code tree, their contributions shown as animated trails. Gource uses OpenGL rendering and requires a 3D-accelerated video card. It supports various version control systems like Git, SVN, Mercurial, and offers extensive parameters for customization, allowing you to easily generate impressive visualizations of your codebase history.

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Development code visualization

Serbia: A Digital Prison – State Surveillance and the Suppression of Civil Society

2025-01-03
Serbia: A Digital Prison – State Surveillance and the Suppression of Civil Society

Amnesty International's report reveals Serbia's use of surveillance technology and digital repression to control and suppress civil society. The report details widespread use of spyware, including NSO Group's Pegasus and a newly disclosed domestically-produced Android spyware, NoviSpy, along with Cellebrite's UFED tools against environmental activists and protest leaders. This constitutes a serious human rights violation and attack on freedom of expression.

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AI-Powered Coding: My Journey with Cline and LLMs

2025-01-27
AI-Powered Coding: My Journey with Cline and LLMs

Paolo Galeone recounts his experience using AI to revamp his SaaS platform, bot.eofferte.eu. Leveraging Cline's VSCode plugin and LLMs like Claude Sonnet 3.5 and Gemini, he redesigned the UI/UX, generating content like privacy policies. Backend development saw AI accelerate code optimization and repetitive tasks, but highlighted the need for human expertise. Multilingual content generation was streamlined, with AI efficiently translating JSON files for multiple Amazon affiliate regions. The key takeaway: AI significantly boosts efficiency but requires developers to validate and integrate AI suggestions, emphasizing the role of human expertise in ensuring quality.

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Development

Debian's Controversial Approach to Rust Dependency Handling

2024-12-26

Debian's integration of Rust has been a long-standing effort, but its dependency handling approach has become a point of contention. Author Ian Jackson argues that faithfully following Rust's Semantic Versioning (semver) in Debian package dependencies is impractical. Fundamental differences exist between Debian's and Rust's dependency management semantics, leading to significant manual work when directly translating Rust's version dependencies. Jackson proposes a radical solution: Debian shouldn't precisely follow upstream Rust semver dependency information, but instead optimistically try various package combinations, letting automated QA discover and fix breakages. This approach, while violating semver, is argued to be mitigated by the Rust community's emphasis on API safety and change notifications, along with Debian's QA mechanisms. The proposal aims to improve the update efficiency of Debian Rust packages, but it might also lead to some dependency combinations failing.

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Development

The Secret to High-Performing Teams: Transactive Memory Systems

2024-12-15
The Secret to High-Performing Teams: Transactive Memory Systems

This article explores the cornerstone of high-performing teams: Transactive Memory Systems (TMS). It's not about individual memory strength, but how teams effectively share and leverage members' knowledge and skills. Three types of team memory are introduced: working, long-term, and transactive memory, with a focus on how TMS enhances team performance. TMS comprises two elements: collaborative patterns and individual expertise. By building a TMS, teams unlock collective intelligence and overcome the impact of member changes. The article recommends methods like the Capability Comb, Team Manual, and deliberate practice to help teams quickly establish and improve their TMS.

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Climate Reanalyzer: Visualizing Daily Global Temperatures

2025-01-21

The Climate Reanalyzer website, from the University of Maine's Climate Change Institute, provides interactive visualizations of daily global temperatures based on ECMWF ERA5 reanalysis data. The site offers interactive charts and maps showing daily mean surface air temperature from 1940 to the present, allowing users to select different regions for analysis. Data updates are delayed by 6-7 days, and users are cautioned to treat extreme temperatures estimated by ERA5 with care. The site also provides access to other climate data, such as sea surface temperature and sea ice extent.

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Ruby Conference Roundup: A Global Overview

2024-12-16

Ruby Video Talks is a website that aggregates information on Ruby developer conferences worldwide. From major events like RubyConf 2024 (70 talks) and Rails World 2024 (46 talks) to smaller regional meetups, the site provides a comprehensive calendar. It highlights key speakers like Matz and offers search functionality by date, location, and topic, making it easy to find relevant events. Upcoming conferences in 2025, such as Balkan Ruby and Friendly.rb, are also listed, promising even more opportunities for the Ruby community.

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LLVM C Library Speeds Up GPUs: Running C Code on GPUs

2024-12-14

The LLVM project has released an exciting GPU C library enabling developers to run libc and libm functions directly on the GPU within C/C++ code. The library supports two main modes: as a supplementary library for offloading languages like OpenMP, CUDA, or HIP; and by directly compiling C/C++ code for the GPU. The article details how to use both modes, including compilation options, linking, and specific builds for AMD and NVIDIA GPUs. This library allows developers to leverage the parallel processing power of GPUs, significantly improving performance without needing deep knowledge of complex GPU programming models.

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Clojure Error Handling: No Silver Bullet, Only Choices

2024-12-14

Clojure offers a diverse range of error-handling approaches, with no single best practice. The article explores several methods: throwing native exceptions, using `ex-info` for data-carrying exceptions, returning error maps, and utilizing various libraries for more sophisticated error handling flows, such as the `anomalies` library or options like `pact` and `failjure`. The author emphasizes that the choice depends on the specific context and that a mix of approaches can coexist within a single project. Developers are empowered to select the most appropriate solution for their needs; Clojure embraces this freedom.

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Development error handling

Programmers Craft a Whimsical Programming Game: Droste's Lair

2024-12-17
Programmers Craft a Whimsical Programming Game: Droste's Lair

Two programmers spent two weeks developing Droste's Lair, a whimsical programming environment game. Players build and count mathematical structures through intuitive drag-and-drop interactions, using an "amb" mechanism for branching execution and recursion. The game, themed around swords and sorcery, presents challenges such as reversing list elements, generating all face card combinations, and counting ways to cover a checkerboard with dominoes. Droste's Lair cleverly blends programming and game elements, offering a novel and engaging way to learn programming and mathematical concepts.

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QuicklyPDF: Your All-in-One Online PDF Solution

2025-01-03
QuicklyPDF: Your All-in-One Online PDF Solution

QuicklyPDF is a free and easy-to-use online platform offering a comprehensive suite of PDF tools. From basic operations like merging, rotating, deleting, reordering, compressing, and extracting pages, to advanced features such as grayscale conversion and PDF repair, QuicklyPDF handles it all. It supports conversions between PDF and various formats including JPG, PNG, BMP, TIFF, Word, PowerPoint, TXT, and Excel. Security features include password protection and unlocking. Whether you're an individual or a business, QuicklyPDF streamlines your PDF workflow.

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The Graphics Codex: Your Ultimate Guide to Computer Graphics

2025-01-26

The Graphics Codex is an interactive learning resource for computer graphics, featuring 400+ cross-referenced equations and diagrams, 14 chapters on physically-based shading and rendering, and multi-platform programming projects with links to external API documentation. It serves as a reference, textbook supplement, or standalone learning guide, updated monthly. Topics range from ray tracing and shadow map shaders to the rendering equation and Fresnel equations, making it ideal for students and professionals alike.

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Klarna Halts Hiring, CEO Claims AI Can Do All Jobs

2024-12-17
Klarna Halts Hiring, CEO Claims AI Can Do All Jobs

Klarna CEO Sebastian Siemiatkowski has claimed that AI can already perform all jobs currently done by humans, leading the fintech company to halt hiring a year ago. The company's workforce has shrunk from 4,500 to 3,500 employees through attrition. While Klarna's website still advertises open positions, a spokesperson clarified that the company is not actively recruiting to expand but filling essential roles, mainly in engineering. This announcement has fueled concerns about AI's impact on the job market.

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Tech Employment

PuzzleZilla: Online Jigsaw Puzzle Maker Launches

2024-12-15

PuzzleZilla is a new online platform allowing users to create custom jigsaw puzzles from any image uploaded from their device or the internet. The site offers a wide variety of pre-categorized puzzles, including cars, babies, cities, animals, flowers, nature, girls, landscapes, dinosaurs, castles, movies, anime, cats, dogs, paintings, food, and fantasy themes. Users can easily create and play their puzzles online.

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Svader: A Svelte Library for GPU-Rendered Components

2024-12-14
Svader: A Svelte Library for GPU-Rendered Components

Svader is a library for creating GPU-rendered Svelte components using WebGL and WebGPU fragment shaders. Developers can write programs in fragment shaders to customize pixel colors and control rendering effects through parameter passing. Supporting Svelte 4 and 5, it offers WebGL and WebGPU rendering modes with built-in parameters like resolution, scale, and time. Svader simplifies GPU rendering with easy-to-use components and provides fallback rendering in environments lacking WebGL or WebGPU support.

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Development

Physically Based Rendering: A Milestone in Ray Tracing

2025-01-16

Physically Based Rendering: From Theory to Implementation is a seminal work in computer graphics, meticulously detailing the construction of modern photorealistic rendering systems through rigorous mathematical theory and executable code. Its impact extends beyond film and game production, influencing product design and architecture. The authors were even awarded an Academy Award for its contribution to filmmaking. The third and fourth editions are now freely available online, offering invaluable learning resources for developers.

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Development ray tracing rendering

A Java JIT Compiler and Runtime in Common Lisp: OpenLDK

2025-02-06
A Java JIT Compiler and Runtime in Common Lisp: OpenLDK

OpenLDK is a Just-In-Time (JIT) compiler and runtime environment for Java, implemented entirely in Common Lisp. It bridges the gap between Java and Common Lisp by incrementally translating Java bytecode into Lisp, then compiling it into native machine code. This unique approach allows seamless mapping of Java classes to Common Lisp Object System (CLOS) classes, enabling effortless integration between Java and Common Lisp codebases. While not designed for high performance, OpenLDK offers a practical solution for integrating Java libraries into a Lisp workflow. Currently, it primarily supports Linux and SBCL, and is a work in progress with many features yet to be implemented, such as support for class files beyond Java 8 and bytecode verification.

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Development

No More Adam: Learning Rate Scaling at Initialization is All You Need

2024-12-18
No More Adam: Learning Rate Scaling at Initialization is All You Need

Researchers introduce SGD-SaI, a novel optimizer improving stochastic gradient descent. SGD-SaI addresses training imbalances by scaling learning rates at initialization for different parameter groups based on their gradient signal-to-noise ratios. Significantly more memory-efficient than AdamW, SGD-SaI matches or surpasses AdamW's performance across various Transformer-based tasks, including ImageNet classification and LLM pretraining. Its robustness and practicality are demonstrated across diverse applications, making it a compelling alternative.

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AI
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