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Beating the Odds: A 20-Year Cancer Battle and the Medical Advancements That Made It Possible

2025-06-09
Beating the Odds: A 20-Year Cancer Battle and the Medical Advancements That Made It Possible

In 2003, Jon Gluck, 38, was diagnosed with multiple myeloma and given 18 months to live. Over two decades later, he's still here, chronicling his experience in a new book. His survival, coupled with a one-third decrease in the US age-adjusted cancer death rate since 1991, showcases a turning tide in the war on cancer. This progress is attributed to breakthroughs like autologous stem-cell harvesting and CAR-T therapy, alongside anti-smoking policies, vaccinations, and improved early screening. While challenges remain, the future of cancer treatment is brighter, offering renewed hope for patients.

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(www.vox.com)
Tech cancer treatment medical advancements CAR-T therapy

GoEnums: Elegant Enum Generation for Go

2025-04-26
GoEnums: Elegant Enum Generation for Go

Tired of Go's lack of native enum support? GoEnums generates comprehensive, type-safe enum implementations from simple constant declarations. Transform basic iota constants into feature-rich enums with string conversion, validation, JSON handling, database integration, and more. GoEnums supports custom fields, case-insensitive parsing, and provides detailed documentation and examples. Simplify your Go code with GoEnums!

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(github.com)
Development

Mastering the Art of Fall Foliage Travel: Timing is Everything

2025-09-23

Planning a fall foliage trip? Knowing when leaves peak is tricky, as timing varies yearly. This guide suggests using fall foliage maps, checking real-time updates, and finalizing plans within two weeks of peak color to account for weather. Pre-planning your hikes or drives, and aiming for early mornings at popular spots to beat the crowds and enjoy the golden sunrise hues, will maximize your autumnal experience.

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(www.explorefall.com)
Misc fall foliage peak season

Rust: A Double-Edged Sword of Efficiency and Challenges

2025-04-15
Rust: A Double-Edged Sword of Efficiency and Challenges

The author shares their experience of spending two years using Rust to write the backend of a B2B SaaS product. Rust boasts exceptional performance, excellent tooling, type safety, and robust error handling. However, the module system and build performance present challenges. While the borrow checker is powerful, it has a steep learning curve. Asynchronous programming, though complex, offers high performance. Overall, the Rust experience is positive, but requires careful consideration of trade-offs.

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(borretti.me)
Development

Balancing Agency and Reliability in LLM-powered Customer Support Agents

2025-04-11
Balancing Agency and Reliability in LLM-powered Customer Support Agents

While Large Language Models (LLMs) are increasingly capable of high-agency tasks, deploying them in high-value use cases like customer support requires prioritizing reliability and consistency. Research reveals that while high-agency agents excel in ideal environments, real-world customer support presents challenges: knowledge gaps, unpredictable user behavior, and time constraints. To address this, a novel metric, pass^k, was developed and tested via simulated customer interactions. Results demonstrate that high-agency agents suffer reliability issues with complex tasks. The solution? The "Give Fin a Task" agent, which enhances reliability by restricting agent autonomy and employing step-by-step instructions, decomposing complex tasks into simpler modules. This approach offers a promising pathway for improving LLM performance in real-world customer support.

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(fin.ai)
AI

CT Scans: Weighing the Tiny Cancer Risk Against Significant Diagnostic Benefits

2025-04-15
CT Scans: Weighing the Tiny Cancer Risk Against Significant Diagnostic Benefits

A new study suggests that while CT scans slightly increase cancer risk (approximately 0.1%), the benefits in disease diagnosis and treatment far outweigh this risk. Experts advise that when a doctor recommends a CT scan, patients should proceed, as the potential benefits in diagnosing illness far outweigh the small added cancer risk. However, the study also notes the increase in CT scan use in recent years and suggests doctors should more carefully weigh risks and benefits, considering diagnostic algorithms and alternative imaging technologies like ultrasound and MRI, and involving patients in the decision-making process.

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(arstechnica.com)
Tech

Running LLMs Locally: A Developer's Guide

2024-12-29
Running LLMs Locally: A Developer's Guide

A developer shares their experience running Large Language Models (LLMs) on a personal computer. Using a high-spec machine (i9 CPU, 4090 GPU, 96GB RAM), along with open-source tools like Ollama and Open WebUI, they successfully run several LLMs for tasks such as code completion and note querying. The article details the hardware, software, models used, and update methods, highlighting the data security and low-latency advantages of running LLMs locally.

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(abishekmuthian.com)
Development Local Run Open Source Tools

WebGPU Sponza Demo: A Stunning Browser Graphics Showcase

2024-12-19
WebGPU Sponza Demo: A Stunning Browser Graphics Showcase

Georgi Nikolov's WebGPU Sponza demo showcases the impressive graphical capabilities of the WebGPU API. Users can navigate the scene using keyboard and mouse controls. However, this demo requires a modern browser with WebGPU support. Currently, Chrome 113+, the latest Firefox Nightly builds, and Safari Technology Preview support WebGPU. Update your browser to the latest version if you want to experience this visually impressive demo.

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(gnikoloff.github.io)
Development graphics rendering browser technology

An Infinitely High Stack of Blocks? Impossible!

2025-08-20

This paper explores a counter-intuitive physics problem: the stability of an infinitely extending stack of blocks. By analyzing torque and center of mass, the author demonstrates that finite-height stacks of blocks can remain stable even when their tops extend far beyond the edge of a table—a result that defies intuition. However, when attempting to extrapolate this to an infinitely high stack, the author finds that regardless of the limiting procedure used, the end result is either no stack at all or a stack that doesn't lean. This reveals the subtleties of limit operations when dealing with infinity and the limitations of intuition.

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(sites.pitt.edu)
Tech mechanics limits

Beyond Vibe Coding: A Responsible Approach to AI-Assisted Development

2025-05-30
Beyond Vibe Coding: A Responsible Approach to AI-Assisted Development

The allure of 'vibe coding,' using AI to rapidly generate code without understanding fundamentals, is prevalent. However, this approach, exemplified by a recent incident exposing an API key due to neglecting security basics, is deeply flawed. The author argues that while AI tools accelerate development, they shouldn't replace core programming knowledge, planning, and testing. True AI-assisted development involves intentional design, thorough understanding of the code's function, and rigorous testing to prevent security vulnerabilities and ensure reliable software. It's about using AI to enhance, not replace, good development practices.

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(newsletter.oberai.dev)
Development Development Process

Psylo: A New Browser That Fights Browser Fingerprinting

2025-06-26
Psylo: A New Browser That Fights Browser Fingerprinting

Mysk, a Canadian company, launched Psylo, an iOS browser designed to combat browser fingerprinting, a technique used for ad tracking and targeting. Psylo isolates tabs into 'silos,' applying unique anti-fingerprinting measures like canvas randomization. It uses the Mysk Private Proxy Network to mask each silo's IP address and encrypts network traffic. Unlike VPNs, Psylo adjusts timezone and language to match each proxy's geolocation for enhanced privacy. The company emphasizes no logging of personally identifiable information or browsing data, only aggregated bandwidth usage for abuse prevention. Psylo offers robust privacy protection at $9.99/month.

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(www.theregister.com)
Tech anti-fingerprinting

Abuse of Copyright Takedown Notices: A Threat to Free Speech

2025-04-27

The Lumen Database reveals a massive wave of abusive copyright takedown notices, used not only against copyright infringement but also to suppress free speech and legitimate reporting. Many notices lack justification, containing false accusations targeting news articles, government information, and business disputes. Some attempt to silence dissent through legal threats, challenging platforms like Google. This raises concerns about internet freedom of speech and access to information, highlighting the dilemma faced by platforms in handling takedown requests.

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(torrentfreak.com)
Tech

ovld: Blazing Fast Multiple Dispatch in Python

2025-06-01
ovld: Blazing Fast Multiple Dispatch in Python

ovld is a lightning-fast multiple dispatch library for Python. It lets you write different versions of the same function for every type signature using annotations, avoiding clunky `isinstance` chains. Unlike Python's `singledispatch`, it handles multiple arguments. ovld boasts exceptional speed, supports dispatching on functions, methods, positional and keyword arguments, and even offers dependent types and code generation. It excels with recursive definitions like tree mapping or serialization and allows creating function variants and medleys for flexible extension.

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(github.com)
Development Multiple Dispatch

MVVM in SwiftUI: Best Practices and Pitfalls

2025-03-19
MVVM in SwiftUI: Best Practices and Pitfalls

This article delves into the best practices and challenges of using the Model-View-ViewModel (MVVM) architectural pattern in SwiftUI. The author argues that while MVVM aligns well with SwiftUI's data flow, its perceived rigidity can introduce problems. The article explains how MVVM works, how to leverage its advantages in SwiftUI, and how to navigate its challenges, including avoiding overusing view models and implementing MVVM in a SwiftUI app. It also compares MVVM to alternative architectural patterns like MVC, the Model-View pattern, and Clean Architecture, analyzing their pros and cons.

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(matteomanferdini.com)
Development Architectural Patterns

Turkish Doctoral Student Released After Arrest for Criticizing Israel

2025-05-11
Turkish Doctoral Student Released After Arrest for Criticizing Israel

Rümeysa Öztürk, a Turkish doctoral student at Tufts University, was released from ICE custody after being detained for over six weeks. Her arrest stemmed from an op-ed she wrote criticizing her university's response to the Israel-Hamas war. A judge ruled her arrest was retaliatory and a violation of her free speech, ordering her immediate release. While released, she still faces potential deportation, sparking debate on the government's power to arrest and deport non-citizens deemed threats to US foreign policy.

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(www.npr.org)
Misc political persecution

Domesday Book: Not Just Taxes, But 11th-Century Big Data?

2025-07-10
Domesday Book: Not Just Taxes, But 11th-Century Big Data?

New research challenges long-held assumptions about William the Conqueror's Domesday Book. Using the earliest surviving manuscript, Exon Domesday, researchers argue the survey wasn't simply about maximizing taxes, but a sophisticated exercise in governmental control—an 11th-century form of big data. The study reveals how William's administration gathered vast economic and territorial data across England in under seven months, processing it with astonishing speed and clarity. The team also proposes a likely identity for the principal scribe, potentially Gerard, William's chancellor. This innovative approach, using only pen, parchment, and human interaction, highlights the ingenuity of the Domesday creators and its significance as a remarkable feat of administrative innovation.

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(www.ox.ac.uk)
Misc governance

Open Source, Self-Hostable Bookmark Manager: Your Privacy, Your Choice

2025-05-01

This open-source, self-hostable bookmark manager prioritizes your privacy. It features a responsive design for all screen sizes, powerful search capabilities for easy content retrieval, a browser extension for seamless web page saving, and supports bulk actions, import/export, and dark/light mode toggling. Crucially, it promises never to sell your data to third parties and offers secure API integration for creating custom solutions. Experience this privacy-focused and powerful bookmark manager today!

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(linkwarden.app)
Development bookmark manager

Fine-tuning LLMs: Solving Problems Prompt Engineering Can't

2025-06-01
Fine-tuning LLMs: Solving Problems Prompt Engineering Can't

This article explores the practical applications of fine-tuning large language models (LLMs), particularly for problems that prompt engineering can't solve. Fine-tuning significantly improves model quality, such as improving task-specific scores, style consistency, and JSON formatting accuracy. Furthermore, it reduces costs, increases speed, and allows achieving similar quality on smaller models, even enabling local deployment for privacy. Fine-tuning also improves model logic, rule-following capabilities, and safety, and allows learning from larger models through distillation. However, the article notes that fine-tuning isn't ideal for adding knowledge; RAG, context loading, or tool calls are recommended instead. The article concludes by recommending Kiln, a tool simplifying the fine-tuning process.

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(getkiln.ai)
AI fine-tuning

Boxie: An Offline Audio Player for Toddlers – Built from Scratch

2025-04-28
Boxie: An Offline Audio Player for Toddlers – Built from Scratch

Inspired by the Game Boy, a father embarked on a journey to build an offline audio player for his 3-year-old son, eliminating the shortcomings of commercial options. The project, named Boxie, uses an ESP32-S3 microcontroller, Micro SD card storage, and a custom-designed PCB and 3D-printed enclosure. The article details the entire process, from learning electronics to soldering SMD components, designing PCBs with EasyEDA, 3D modeling with Fusion 360, and writing the firmware. The result is a robust, offline, and child-friendly audio player showcasing impressive DIY skills and parental dedication.

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(mariozechner.at)
Hardware

Building a Code-Editing Agent in 94 Lines of Ruby

2025-05-16

This article challenges the perceived difficulty of building a code-editing agent, showcasing a fully functional one built in just 94 lines of Ruby using the RubyLLM gem. The agent leverages a Large Language Model (LLM) and three tools – read file, list files, and edit file – to perform code editing tasks. The author details the implementation of each tool and demonstrates the agent's capabilities by building an ASCII Minesweeper game. A shell command execution tool is added to enhance functionality, resulting in a self-testing code-editing agent.

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(radanskoric.com)
Development

Moon-Based Data Centers: A Backup for Earth's Civilization?

2025-02-26
Moon-Based Data Centers: A Backup for Earth's Civilization?

SpaceX is launching a Falcon 9 rocket carrying Intuitive Machines' lunar lander, which includes a mini data center weighing just 1 kg and boasting 8 TB of SSD storage. This is Lonestar Data Holdings' proof-of-concept mission to bring moon-based data centers to reality. The advantages are numerous: enhanced data security from earthly disasters and conflict; data sovereignty bypassing national restrictions; and low-temperature operation leading to energy efficiency and improved performance. However, challenges remain: high latency, difficult maintenance, and cybersecurity concerns. Despite these, experts remain optimistic about the future of lunar data centers, viewing them as a potential driver for space technology development.

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(spectrum.ieee.org)
Tech lunar data center

150 Years of the Metre: From French Revolution to Laser Light

2025-05-23
150 Years of the Metre: From French Revolution to Laser Light

The 1875 Metre Convention standardized measurement, ending inconsistent units across countries. Initially defined as one ten-millionth of the distance from the North Pole to the equator through Paris, the metre's definition has evolved with scientific advancements. Early definitions relied on platinum-iridium bars, then krypton-86 light wavelengths. Today, it's defined by the speed of light, enabling precise measurements like the Moon's gradual recession from Earth. Despite global adoption, remnants of imperial units persist in various contexts, highlighting the ongoing challenges of standardization.

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(www.abc.net.au)
Tech Metric System Measurement

Deep Dive into Kiki KaiKai's Hardware: Taito's Sprite-Based Arcade Gem

2025-05-21
Deep Dive into Kiki KaiKai's Hardware: Taito's Sprite-Based Arcade Gem

This post delves into the hardware architecture of the arcade game Kiki KaiKai. Released in 1986, this game uses a sprite-based rendering system, not a unique feature at the time. Key hardware components include a YM2203 FM synthesizer, a Taito-customized MCU (JPH1020P) based on the Motorola 6801, and a Z80 CPU. The author details the 12-bit RGB color display, PAL programmable array logic, and high-speed RAM. A unique visual artifact is analyzed, attributed to the switching between sprite and background rendering. The post concludes with details of the PCB, including interesting finds in the manual and stickers, such as a Taito seal featuring what appears to be a Prussian eagle.

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(nicole.express)
Hardware hardware analysis

Apple WWDC2025: Supercharging Developer Tools for the Future of Apps

2025-06-09
Apple WWDC2025: Supercharging Developer Tools for the Future of Apps

Apple's WWDC2025 keynote unveiled significant updates empowering developers to build smarter, more beautiful, and engaging apps. Xcode 26 integrates large language models like ChatGPT, boosting coding efficiency. The new Foundation Models framework allows developers to leverage on-device AI for offline, privacy-preserving intelligent apps. A refined 'Liquid Glass' design language brings a fresh visual experience. Further enhancements include upgraded game development tools, improved child online safety features, and increased App Store accessibility. These powerful tools and resources are designed to help developers create the next generation of exceptional apps.

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(www.apple.com)
Development Apple Developers

Rust for C++ Programmers: A Practical Guide

2025-05-31

This book serves as a practical guide for C++ programmers transitioning to Rust. It translates common C++ patterns into idiomatic Rust, using concrete code examples and discussing engineering trade-offs. The book is designed for both sequential and random-access reading, perfect for when you encounter a Rust problem and think, "I know how to do this in C++". Written by experts at Brown University's Cognitive Engineering Lab, it focuses on accuracy and detail, with no AI-generated content.

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(cel.cs.brown.edu)
Development

Ellison: Governments Need to Pool All Data for AI Success

2025-02-13
Ellison: Governments Need to Pool All Data for AI Success

Oracle CEO Larry Ellison argues that governments must consolidate all data, including genomic information, to leverage AI effectively for improved services and security. Speaking at the World Government Summit, he envisions AI-driven advancements in healthcare and agriculture, but acknowledges the potential for widespread surveillance. Ellison highlights Oracle's substantial investment in AI infrastructure, including a massive new data center and participation in the Stargate project, to support this vision.

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(www.theregister.com)
Tech Data Consolidation Government

Scraperr: Precise Web Data Extraction with XPath

2025-05-11
Scraperr: Precise Web Data Extraction with XPath

Scraperr is a self-hosted web scraping application that uses XPath selectors for precise data extraction. It offers a clean interface to manage scraping jobs, view results, and export data in various formats. Features include queue management, domain spidering, custom headers, media downloads, results visualization, and notification channels. Remember to respect robots.txt, terms of service, and implement rate limiting. Use only on websites that explicitly permit scraping.

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(github.com)
Development

Lil Nas X Copyright Case: Algorithmic Recommendation Not a Get-Out-of-Jail-Free Card

2025-05-20
Lil Nas X Copyright Case: Algorithmic Recommendation Not a Get-Out-of-Jail-Free Card

Freelance artist Rodney Woodland sued Lil Nas X for copyright infringement over semi-nude photos posted on Instagram. The court dismissed the case, finding Woodland's photos lacked sufficient engagement to prove Lil Nas X had access to them, and that substantial similarity between the photos was lacking. The court delved into the impact of social media algorithms on the copyright "access" standard, stating that merely posting works to social media isn't enough to prove access; it requires showing the defendant had a reasonable chance of seeing the plaintiff's work through the platform's algorithm or content-sharing policies. This case sets a significant precedent for future social media algorithmic recommendation and copyright litigation.

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(blog.ericgoldman.org)
Law

Nostalgia Trip: Why Early Computers Were More Fun

2025-04-18

This article explores why older generations find early computers more enjoyable than modern ones. The author argues that the simplicity and limitations of early hardware – slow processors, low resolutions, limited memory – forced creative problem-solving, making the experience more engaging. The largely text-based internet fostered stronger human interaction, lacking the pervasive advertising and passive content consumption of today. The author posits that the appeal lay in the exclusivity; only those truly passionate about computers invested the time, creating a tight-knit community. As computers became ubiquitous and user-friendly, this unique aspect faded, replaced by accessibility but at the cost of depth and challenge.

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(www.datagubbe.se)
Misc computer culture
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